Load Specifications
Load data in caliber .375 Ruger with .375 | 301gr | RWS UNI Classic bullet and 98 powders. The key underlying parameters are shown in the table above. The recommended powders for this cartridge and bullet combination are Alliant Power Pro 2000-MR, Hodgdon Superformance and Alliant Reloder-17.
Important Notice: DO NOT go below Minimum Charge or above Maximum Charge. Since we have no control over the equipment and components used, any responsibility and liability for the results achieved is rejected.
Only powders/loads that match the current filter criteria are displayed: max pressure of a load ≤ 90% of max. standardized pressure, fill rate ≥ 80% and propellant combustion ≥ 95%. Use the sliders above the tables to adjust these thresholds.
Charge: Powder weight in grains. Start with the minimum load and work up carefully.
FR (Fill Rate): Case fill as a percentage. Values above 100% mean compressed loads.
MaxP / %: Maximum chamber pressure in bar and as a percentage of the standardized maximum for this caliber.
V(0): Muzzle velocity in feet per second (fps) at the standardized barrel length.
z (Powder Burn): Estimated propellant combustion percentage at bullet exit.
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You can find more information in our FAQ: How can I use the Personalized Load Calculator?
Max Load - Barrel Length: 23"
| Powder | Charge | FR | MaxP | % | V(0) | z |
|---|---|---|---|---|---|---|
| Accurate 2015 | <<locked>> | 84% | 55,651 psi | 90% | 2346 fps | 100% |
| Accurate 2495 | <<locked>> | 88% | 54,331 psi | 88% | 2369 fps | 100% |
| Accurate 2520 | <<locked>> | 84% | 56,072 psi | 90% | 2428 fps | 100% |
| Accurate 2700 | <<locked>> | 88% | 53,417 psi | 86% | 2372 fps | 97.4% |
| Accurate 3100ᴾ | <<locked>> | 100% | 41,089 psi | 66% | 2283 fps | 96.7% |
| Accurate 4064 | <<locked>> | 90% | 54,346 psi | 88% | 2411 fps | 100% |
| Accurate 4350 | <<locked>> | 98% | 53,867 psi | 87% | 2487 fps | 99.8% |
| ADI AR 2206H | <<locked>> | 86% | 54,665 psi | 88% | 2438 fps | 100% |
| ADI AR 2208 | <<locked>> | 92% | 55,506 psi | 89% | 2438 fps | 100% |
| ADI Benchmark 8208 | <<locked>> | 84% | 53,722 psi | 87% | 2395 fps | 100% |
| Alliant AR-Comp | <<locked>> | 84% | 54,592 psi | 88% | 2369 fps | 100% |
| Alliant Power Pro 2000-MR | <<locked>> | 88% | 54,056 psi | 87% | 2539 fps | 100% |
| Alliant Reloder- TS 15.5 | <<locked>> | 92% | 55,492 psi | 89% | 2454 fps | 100% |
| Alliant Reloder-15 | <<locked>> | 88% | 52,707 psi | 85% | 2431 fps | 99.9% |
| Alliant Reloder-16ᴾ | <<locked>> | 100% | 54,998 psi | 89% | 2533 fps | 100% |
| Alliant Reloder-17 | <<locked>> | 94% | 52,823 psi | 85% | 2520 fps | 100% |
| Alliant Reloder-23ᴾ | <<locked>> | 100% | 39,479 psi | 64% | 2316 fps | 99.4% |
| Alliant Reloder-26ᴾ | <<locked>> | 100% | 43,990 psi | 71% | 2454 fps | 98.8% |
| Baschieri & Pellagri 107 | <<locked>> | 86% | 54,331 psi | 88% | 2451 fps | 99.9% |
| Bofors RP3 | <<locked>> | 90% | 52,707 psi | 85% | 2428 fps | 100% |
| Bofors RP7 | <<locked>> | 94% | 52,924 psi | 85% | 2402 fps | 97.6% |
| Hodgdon Benchmark | <<locked>> | 84% | 55,376 psi | 89% | 2379 fps | 100% |
| Hodgdon BL-C2 | <<locked>> | 84% | 52,968 psi | 85% | 2421 fps | 100% |
| Hodgdon CFE223 | <<locked>> | 82% | 54,824 psi | 88% | 2507 fps | 100% |
| Hodgdon H380 | <<locked>> | 90% | 53,737 psi | 87% | 2441 fps | 99.6% |
| Hodgdon H414 | <<locked>> | 96% | 53,142 psi | 86% | 2484 fps | 98.3% |
| Hodgdon H4350 | <<locked>> | 94% | 53,911 psi | 87% | 2451 fps | 97.2% |
| Hodgdon H4895 | <<locked>> | 86% | 55,187 psi | 89% | 2448 fps | 100% |
| Hodgdon Hybrid 100Vᴾ | <<locked>> | 100% | 51,300 psi | 83% | 2425 fps | 100% |
| Hodgdon LEVERevolution | <<locked>> | 88% | 54,462 psi | 88% | 2474 fps | 100% |
| Hodgdon Superformance | <<locked>> | 96% | 53,737 psi | 87% | 2516 fps | 98% |
| Hodgdon TrailBossᴾ | <<locked>> | 100% | 35,636 psi | 57% | 1476 fps | 100% |
| Hodgdon VARGET | <<locked>> | 86% | 53,011 psi | 85% | 2405 fps | 100% |
| IMR 3031 | <<locked>> | 86% | 55,259 psi | 89% | 2428 fps | 100% |
| IMR 4064 | <<locked>> | 90% | 55,013 psi | 89% | 2421 fps | 100% |
| IMR 4166 Enduron | <<locked>> | 88% | 55,071 psi | 89% | 2408 fps | 98.4% |
| IMR 4350 | <<locked>> | 98% | 53,127 psi | 86% | 2425 fps | 97.7% |
| IMR 4451 Enduron | <<locked>> | 94% | 54,868 psi | 88% | 2431 fps | 98.3% |
| IMR 4831ᴾ | <<locked>> | 100% | 54,288 psi | 87% | 2477 fps | 99.9% |
| IMR 4895 | <<locked>> | 88% | 54,056 psi | 87% | 2457 fps | 100% |
| IMR 8208 XBR | <<locked>> | 84% | 53,722 psi | 87% | 2395 fps | 100% |
| Lovex D073.6 | <<locked>> | 86% | 54,375 psi | 88% | 2415 fps | 100% |
| Lovex S060 | <<locked>> | 86% | 54,157 psi | 87% | 2375 fps | 100% |
| Lovex S062 | <<locked>> | 90% | 54,969 psi | 89% | 2418 fps | 100% |
| Lovex S065 | <<locked>> | 96% | 54,201 psi | 87% | 2425 fps | 99.2% |
| Lovex S070 | <<locked>> | 98% | 55,042 psi | 89% | 2454 fps | 98.6% |
| Norma 201 | <<locked>> | 86% | 53,519 psi | 86% | 2392 fps | 100% |
| Norma 202 | <<locked>> | 86% | 53,896 psi | 87% | 2388 fps | 100% |
| Norma 203B | <<locked>> | 90% | 55,463 psi | 89% | 2467 fps | 100% |
| Norma 204 | <<locked>> | 98% | 53,679 psi | 86% | 2467 fps | 96.6% |
| Norma MRPᴾ | <<locked>> | 100% | 44,063 psi | 71% | 2415 fps | 96.3% |
| Norma URP | <<locked>> | 98% | 52,968 psi | 85% | 2477 fps | 99.8% |
| Ramshot Big Game | <<locked>> | 90% | 56,043 psi | 90% | 2490 fps | 100% |
| Ramshot Hunterᴾ | <<locked>> | 100% | 55,172 psi | 89% | 2516 fps | 99.2% |
| Ramshot TAC | <<locked>> | 84% | 53,766 psi | 87% | 2411 fps | 99.3% |
| Ramshot Wild Boar | <<locked>> | 84% | 53,476 psi | 86% | 2428 fps | 100% |
| Ramshot X-Terminator | <<locked>> | 82% | 54,447 psi | 88% | 2395 fps | 100% |
| ReloadSwiss RS 14ᴾ | <<locked>> | 100% | 36,143 psi | 58% | 1509 fps | 100% |
| ReloadSwiss RS 50 | <<locked>> | 90% | 53,882 psi | 87% | 2421 fps | 98.7% |
| ReloadSwiss RS 52 | <<locked>> | 86% | 52,982 psi | 85% | 2487 fps | 99.9% |
| ReloadSwiss RS 60 | <<locked>> | 92% | 52,620 psi | 85% | 2520 fps | 100% |
| ReloadSwiss RS 62 | <<locked>> | 98% | 53,432 psi | 86% | 2507 fps | 99.7% |
| ReloadSwiss RS 70 | <<locked>> | 98% | 53,084 psi | 86% | 2530 fps | 99.6% |
| Rottweil R 901 | <<locked>> | 84% | 54,375 psi | 88% | 2372 fps | 100% |
| Rottweil R 902 | <<locked>> | 88% | 53,925 psi | 87% | 2388 fps | 100% |
| Rottweil R 903 | <<locked>> | 92% | 52,518 psi | 85% | 2418 fps | 100% |
| Rottweil R 907 | <<locked>> | 94% | 52,924 psi | 85% | 2402 fps | 97.6% |
| Shooters World Long Rifle | <<locked>> | 96% | 54,201 psi | 87% | 2425 fps | 99.2% |
| Shooters World Match Rifle | <<locked>> | 86% | 54,375 psi | 88% | 2415 fps | 100% |
| Shooters World Precision | <<locked>> | 90% | 54,969 psi | 89% | 2418 fps | 100% |
| Shooters World SW4350 | <<locked>> | 98% | 55,042 psi | 89% | 2454 fps | 98.6% |
| SNPE Vectan SP 11 | <<locked>> | 92% | 54,244 psi | 87% | 2474 fps | 100% |
| SNPE Vectan SP 7 | <<locked>> | 86% | 55,912 psi | 90% | 2441 fps | 99.7% |
| SNPE Vectan SP 9 | <<locked>> | 86% | 52,953 psi | 85% | 2411 fps | 100% |
| SNPE Vectan Tubal 3000 | <<locked>> | 86% | 54,940 psi | 89% | 2336 fps | 100% |
| SNPE Vectan Tubal 5000 | <<locked>> | 92% | 55,172 psi | 89% | 2336 fps | 100% |
| SNPE Vectan Tubal 7000 | <<locked>> | 96% | 54,302 psi | 87% | 2382 fps | 98.2% |
| Somchem S321 | <<locked>> | 82% | 54,737 psi | 88% | 2421 fps | 100% |
| Somchem S335 | <<locked>> | 86% | 54,375 psi | 88% | 2336 fps | 100% |
| Somchem S341 | <<locked>> | 86% | 55,376 psi | 89% | 2431 fps | 100% |
| Somchem S355 | <<locked>> | 92% | 53,084 psi | 86% | 2421 fps | 100% |
| Somchem S365ᴾ | <<locked>> | 100% | 50,792 psi | 82% | 2474 fps | 100% |
| Somchem S385ᴾ | <<locked>> | 100% | 47,340 psi | 76% | 2375 fps | 96.6% |
| Vihtavuori N130 | <<locked>> | 82% | 54,636 psi | 88% | 2300 fps | 100% |
| Vihtavuori N133 | <<locked>> | 86% | 55,187 psi | 89% | 2320 fps | 100% |
| Vihtavuori N135 | <<locked>> | 88% | 53,737 psi | 87% | 2356 fps | 100% |
| Vihtavuori N140 | <<locked>> | 88% | 54,433 psi | 88% | 2372 fps | 100% |
| Vihtavuori N150 | <<locked>> | 94% | 54,476 psi | 88% | 2402 fps | 100% |
| Vihtavuori N160 | <<locked>> | 98% | 55,506 psi | 89% | 2470 fps | 99.8% |
| Vihtavuori N530 | <<locked>> | 84% | 54,143 psi | 87% | 2395 fps | 100% |
| Vihtavuori N540 | <<locked>> | 90% | 56,086 psi | 90% | 2411 fps | 100% |
| Vihtavuori N550 | <<locked>> | 98% | 54,375 psi | 88% | 2477 fps | 99.7% |
| Vihtavuori N555ᴾ | <<locked>> | 100% | 43,163 psi | 70% | 2379 fps | 99.2% |
| Winchester 6.5 StaBALL | <<locked>> | 98% | 55,738 psi | 90% | 2451 fps | 100% |
| Winchester 748 | <<locked>> | 84% | 54,070 psi | 87% | 2434 fps | 100% |
| Winchester 760 | <<locked>> | 96% | 53,359 psi | 86% | 2487 fps | 98.3% |
| Winchester StaBALL HDᴾ | <<locked>> | 100% | 35,215 psi | 57% | 2320 fps | 99.4% |
| Winchester StaBALL Match | <<locked>> | 86% | 52,852 psi | 85% | 2421 fps | 100% |
Recommended = one of the top powders for this cartridge and bullet combination.
Start Load - Barrel Length: 23"
| Powder | Charge | FR | MaxP | % | V(0) | z |
|---|---|---|---|---|---|---|
| Accurate 2015 | <<locked>> | 80% | 49,095 psi | 79% | 2267 fps | 100% |
| Accurate 2495 | <<locked>> | 80% | 41,916 psi | 68% | 2211 fps | 100% |
| Accurate 2520 | <<locked>> | 80% | 48,805 psi | 79% | 2339 fps | 100% |
| Accurate 2700 | <<locked>> | 82% | 43,961 psi | 71% | 2234 fps | 95.3% |
| Accurate 3100 | <<locked>> | 96% | 35,955 psi | 58% | 2195 fps | 95.1% |
| Accurate 4064 | <<locked>> | 80% | 39,653 psi | 64% | 2211 fps | 100% |
| Accurate 4350 | <<locked>> | 82% | 30,995 psi | 50% | 2106 fps | 95.3% |
| ADI AR 2206H | <<locked>> | 80% | 45,281 psi | 73% | 2306 fps | 99.6% |
| ADI AR 2208 | <<locked>> | 80% | 38,551 psi | 62% | 2178 fps | 98.1% |
| ADI Benchmark 8208 | <<locked>> | 80% | 47,369 psi | 76% | 2310 fps | 100% |
| Alliant AR-Comp | <<locked>> | 80% | 47,819 psi | 77% | 2290 fps | 100% |
| Alliant Power Pro 2000-MR | 65.4 gr | 80% | 41,176 psi | 66% | 2339 fps | 98.7% |
| Alliant Reloder- TS 15.5 | <<locked>> | 80% | 38,203 psi | 62% | 2198 fps | 99.2% |
| Alliant Reloder-15 | <<locked>> | 80% | 41,002 psi | 66% | 2254 fps | 98.8% |
| Alliant Reloder-16 | <<locked>> | 82% | 31,633 psi | 51% | 2119 fps | 95.4% |
| Alliant Reloder-17 | 64.4 gr | 80% | 32,967 psi | 53% | 2178 fps | 97.8% |
| Alliant Reloder-23 | <<locked>> | 88% | 27,383 psi | 44% | 2041 fps | 95.1% |
| Alliant Reloder-26 | <<locked>> | 92% | 33,344 psi | 54% | 2238 fps | 95.3% |
| Baschieri & Pellagri 107 | <<locked>> | 80% | 44,556 psi | 72% | 2313 fps | 99% |
| Bofors RP3 | <<locked>> | 80% | 37,927 psi | 61% | 2205 fps | 99.3% |
| Bofors RP7 | <<locked>> | 88% | 43,990 psi | 71% | 2267 fps | 95.6% |
| Hodgdon Benchmark | <<locked>> | 80% | 49,139 psi | 79% | 2297 fps | 100% |
| Hodgdon BL-C2 | <<locked>> | 80% | 46,238 psi | 74% | 2329 fps | 100% |
| Hodgdon CFE223 | <<locked>> | 80% | 51,053 psi | 82% | 2454 fps | 99.9% |
| Hodgdon H380 | <<locked>> | 80% | 38,609 psi | 62% | 2205 fps | 97.2% |
| Hodgdon H414 | <<locked>> | 88% | 40,799 psi | 66% | 2293 fps | 95.6% |
| Hodgdon H4350 | <<locked>> | 88% | 44,657 psi | 72% | 2313 fps | 95% |
| Hodgdon H4895 | <<locked>> | 80% | 45,716 psi | 74% | 2316 fps | 99.8% |
| Hodgdon Hybrid 100V | <<locked>> | 80% | 27,209 psi | 44% | 1988 fps | 95.4% |
| Hodgdon LEVERevolution | <<locked>> | 80% | 41,669 psi | 67% | 2293 fps | 99.7% |
| Hodgdon Superformance | 76.6 gr | 90% | 43,424 psi | 70% | 2356 fps | 95.7% |
| Hodgdon TrailBoss | <<locked>> | 80% | 26,513 psi | 43% | 1316 fps | 100% |
| Hodgdon VARGET | <<locked>> | 80% | 43,830 psi | 71% | 2274 fps | 99.7% |
| IMR 3031 | <<locked>> | 80% | 45,411 psi | 73% | 2306 fps | 100% |
| IMR 4064 | <<locked>> | 80% | 40,437 psi | 65% | 2208 fps | 98.7% |
| IMR 4166 Enduron | <<locked>> | 80% | 42,917 psi | 69% | 2224 fps | 95.9% |
| IMR 4350 | <<locked>> | 92% | 44,034 psi | 71% | 2290 fps | 95.7% |
| IMR 4451 Enduron | <<locked>> | 84% | 40,408 psi | 65% | 2208 fps | 95.1% |
| IMR 4831 | <<locked>> | 82% | 30,226 psi | 49% | 2073 fps | 95% |
| IMR 4895 | <<locked>> | 80% | 42,003 psi | 68% | 2280 fps | 99.3% |
| IMR 8208 XBR | <<locked>> | 80% | 47,369 psi | 76% | 2310 fps | 100% |
| Lovex D073.6 | <<locked>> | 80% | 44,585 psi | 72% | 2290 fps | 100% |
| Lovex S060 | <<locked>> | 80% | 45,179 psi | 73% | 2251 fps | 99.6% |
| Lovex S062 | <<locked>> | 80% | 40,350 psi | 65% | 2211 fps | 99.7% |
| Lovex S065 | <<locked>> | 82% | 35,375 psi | 57% | 2123 fps | 95.2% |
| Lovex S070 | <<locked>> | 88% | 40,364 psi | 65% | 2234 fps | 95.6% |
| Norma 201 | <<locked>> | 80% | 44,454 psi | 72% | 2264 fps | 99.9% |
| Norma 202 | <<locked>> | 80% | 44,730 psi | 72% | 2267 fps | 100% |
| Norma 203B | <<locked>> | 80% | 40,364 psi | 65% | 2244 fps | 99% |
| Norma 204 | <<locked>> | 94% | 46,891 psi | 76% | 2369 fps | 95% |
| Norma MRP | <<locked>> | 98% | 41,234 psi | 66% | 2365 fps | 95.3% |
| Norma URP | <<locked>> | 82% | 31,488 psi | 51% | 2110 fps | 95.2% |
| Ramshot Big Game | <<locked>> | 80% | 39,885 psi | 64% | 2257 fps | 98.9% |
| Ramshot Hunter | <<locked>> | 88% | 37,362 psi | 60% | 2234 fps | 95.4% |
| Ramshot TAC | <<locked>> | 80% | 47,239 psi | 76% | 2320 fps | 98.4% |
| Ramshot Wild Boar | <<locked>> | 80% | 46,775 psi | 75% | 2336 fps | 99.7% |
| Ramshot X-Terminator | <<locked>> | 80% | 50,937 psi | 82% | 2349 fps | 99.9% |
| ReloadSwiss RS 14 | <<locked>> | 80% | 26,876 psi | 43% | 1348 fps | 100% |
| ReloadSwiss RS 50 | <<locked>> | 80% | 39,102 psi | 63% | 2192 fps | 95.6% |
| ReloadSwiss RS 52 | <<locked>> | 80% | 43,207 psi | 70% | 2343 fps | 99.1% |
| ReloadSwiss RS 60 | <<locked>> | 80% | 35,070 psi | 56% | 2234 fps | 99.9% |
| ReloadSwiss RS 62 | <<locked>> | 84% | 32,953 psi | 53% | 2165 fps | 95.6% |
| ReloadSwiss RS 70 | <<locked>> | 86% | 35,476 psi | 57% | 2221 fps | 95.6% |
| Rottweil R 901 | <<locked>> | 80% | 48,341 psi | 78% | 2293 fps | 100% |
| Rottweil R 902 | <<locked>> | 80% | 42,279 psi | 68% | 2224 fps | 99.8% |
| Rottweil R 903 | <<locked>> | 80% | 35,621 psi | 57% | 2156 fps | 98.7% |
| Rottweil R 907 | <<locked>> | 88% | 43,990 psi | 71% | 2267 fps | 95.6% |
| Shooters World Long Rifle | <<locked>> | 82% | 35,375 psi | 57% | 2123 fps | 95.2% |
| Shooters World Match Rifle | <<locked>> | 80% | 44,585 psi | 72% | 2290 fps | 100% |
| Shooters World Precision | <<locked>> | 80% | 40,350 psi | 65% | 2211 fps | 99.7% |
| Shooters World SW4350 | <<locked>> | 88% | 40,364 psi | 65% | 2234 fps | 95.6% |
| SNPE Vectan SP 11 | <<locked>> | 80% | 36,550 psi | 59% | 2201 fps | 98.2% |
| SNPE Vectan SP 7 | <<locked>> | 80% | 45,658 psi | 74% | 2300 fps | 98.5% |
| SNPE Vectan SP 9 | <<locked>> | 80% | 43,758 psi | 70% | 2280 fps | 99.5% |
| SNPE Vectan Tubal 3000 | <<locked>> | 80% | 45,759 psi | 74% | 2218 fps | 100% |
| SNPE Vectan Tubal 5000 | <<locked>> | 80% | 38,130 psi | 61% | 2110 fps | 100% |
| SNPE Vectan Tubal 7000 | <<locked>> | 86% | 39,247 psi | 63% | 2159 fps | 95% |
| Somchem S321 | <<locked>> | 80% | 51,285 psi | 83% | 2379 fps | 100% |
| Somchem S335 | <<locked>> | 80% | 45,382 psi | 73% | 2221 fps | 100% |
| Somchem S341 | <<locked>> | 80% | 45,368 psi | 73% | 2293 fps | 99.6% |
| Somchem S355 | <<locked>> | 80% | 36,535 psi | 59% | 2162 fps | 98.7% |
| Somchem S365 | <<locked>> | 80% | 26,527 psi | 43% | 2024 fps | 96.7% |
| Somchem S385 | <<locked>> | 96% | 41,539 psi | 67% | 2283 fps | 95% |
| Vihtavuori N130 | <<locked>> | 80% | 51,590 psi | 83% | 2264 fps | 100% |
| Vihtavuori N133 | <<locked>> | 80% | 46,108 psi | 74% | 2211 fps | 100% |
| Vihtavuori N135 | <<locked>> | 80% | 41,843 psi | 67% | 2205 fps | 100% |
| Vihtavuori N140 | <<locked>> | 80% | 42,293 psi | 68% | 2211 fps | 100% |
| Vihtavuori N150 | <<locked>> | 80% | 34,621 psi | 56% | 2106 fps | 99.2% |
| Vihtavuori N160 | <<locked>> | 82% | 32,880 psi | 53% | 2110 fps | 95.7% |
| Vihtavuori N530 | <<locked>> | 80% | 47,529 psi | 77% | 2306 fps | 100% |
| Vihtavuori N540 | <<locked>> | 80% | 40,683 psi | 66% | 2205 fps | 100% |
| Vihtavuori N550 | <<locked>> | 82% | 32,387 psi | 52% | 2113 fps | 95.3% |
| Vihtavuori N555 | <<locked>> | 88% | 29,196 psi | 47% | 2103 fps | 95.2% |
| Winchester 6.5 StaBALL | <<locked>> | 80% | 30,748 psi | 50% | 2047 fps | 97.1% |
| Winchester 748 | <<locked>> | 80% | 47,239 psi | 76% | 2346 fps | 100% |
| Winchester 760 | <<locked>> | 88% | 40,973 psi | 66% | 2297 fps | 95.6% |
| Winchester StaBALL HD | <<locked>> | 92% | 27,354 psi | 44% | 2103 fps | 95.5% |
| Winchester StaBALL Match | <<locked>> | 80% | 43,207 psi | 70% | 2283 fps | 99.7% |
Recommended = one of the top powders for this cartridge and bullet combination.
ᴾ possible press load - work up slowly to this load while watching for signs of excessive pressure.
This overview compares 98 powders for .375 Ruger loaded with the .375 | 301gr | RWS UNI Classic. Alliant Power Pro 2000-MR delivers the highest muzzle velocity at 2,539 fps; across all powders the maximum-charge window runs from 1,476 fps to 2,539 fps. Accurate 3100 gives the best case fill at 100 %, and 98 of the 98 powders fall inside the usable 80–100 % fill window.
Relative to the caliber's maximum pressure (428 MPa), the top charges use 57–90 %, leaving at least 10 % headroom. The 301.0 gr projectile in 0.375" calls for a 1:6.0 twist; slower twists will usually not stabilise this weight. Accurate 3100, Alliant Reloder-16, Alliant Reloder-23 reach 100 % fill or more at maximum charge, so these are compressed loads: they need a long drop tube to seat cleanly and react sensitively to the case capacity of your own brass lot. Alliant Power Pro 2000-MR, Hodgdon Superformance, Alliant Reloder-17 rank at the top here: for .375 Ruger with the .375 | 301gr | RWS UNI Classic they combine a high case fill with complete burn and sit in the upper velocity band. Always begin at the start load and work up in small increments while checking case and primer for pressure signs.