Load Specifications
Load data in caliber .375 Blaser Mag. with .375 | 270gr | Nosler CT FailSafe bullet and 98 powders. The key underlying parameters are shown in the table above. The recommended powders for this cartridge and bullet combination are ReloadSwiss RS 60, Alliant Reloder-17 and Alliant Power Pro 2000-MR.
Important Notice: DO NOT go below Minimum Charge or above Maximum Charge. Since we have no control over the equipment and components used, any responsibility and liability for the results achieved is rejected.
Only powders/loads that match the current filter criteria are displayed: max pressure of a load ≤ 90% of max. standardized pressure, fill rate ≥ 80% and propellant combustion ≥ 95%. Use the sliders above the tables to adjust these thresholds.
Charge: Powder weight in grains. Start with the minimum load and work up carefully.
FR (Fill Rate): Case fill as a percentage. Values above 100% mean compressed loads.
MaxP / %: Maximum chamber pressure in bar and as a percentage of the standardized maximum for this caliber.
V(0): Muzzle velocity in feet per second (fps) at the standardized barrel length.
z (Powder Burn): Estimated propellant combustion percentage at bullet exit.
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You can find more information in our FAQ: How can I use the Personalized Load Calculator?
Max Load - Barrel Length: 25.6"
| Powder | Charge | FR | MaxP | % | V(0) | z |
|---|---|---|---|---|---|---|
| Accurate 2015 | <<locked>> | 84% | 53,098 psi | 87% | 2575 fps | 100% |
| Accurate 2460 | <<locked>> | 82% | 54,752 psi | 90% | 2644 fps | 100% |
| Accurate 2495 | <<locked>> | 90% | 54,694 psi | 90% | 2641 fps | 100% |
| Accurate 2520 | <<locked>> | 84% | 53,243 psi | 87% | 2661 fps | 100% |
| Accurate 2700 | <<locked>> | 90% | 54,244 psi | 89% | 2641 fps | 97.1% |
| Accurate 4064 | <<locked>> | 92% | 54,563 psi | 90% | 2684 fps | 100% |
| Accurate 4350ᴾ | <<locked>> | 100% | 54,012 psi | 89% | 2762 fps | 99.7% |
| ADI AR 2206H | <<locked>> | 86% | 52,214 psi | 86% | 2671 fps | 99.9% |
| ADI AR 2208 | <<locked>> | 92% | 53,156 psi | 87% | 2671 fps | 99.8% |
| ADI Benchmark 8208 | <<locked>> | 86% | 54,665 psi | 90% | 2671 fps | 100% |
| Alliant AR-Comp | <<locked>> | 84% | 51,808 psi | 85% | 2602 fps | 100% |
| Alliant Power Pro 2000-MR | <<locked>> | 90% | 55,056 psi | 90% | 2835 fps | 99.9% |
| Alliant Reloder- TS 15.5 | <<locked>> | 92% | 52,997 psi | 87% | 2694 fps | 100% |
| Alliant Reloder-15 | <<locked>> | 90% | 53,374 psi | 88% | 2710 fps | 99.9% |
| Alliant Reloder-16ᴾ | <<locked>> | 100% | 52,243 psi | 86% | 2769 fps | 99.7% |
| Alliant Reloder-17 | <<locked>> | 96% | 53,258 psi | 87% | 2805 fps | 100% |
| Alliant Reloder-23ᴾ | <<locked>> | 100% | 37,275 psi | 61% | 2523 fps | 98.6% |
| Alliant Reloder-26ᴾ | <<locked>> | 100% | 41,220 psi | 68% | 2664 fps | 97.6% |
| Baschieri & Pellagri 107 | <<locked>> | 86% | 51,648 psi | 85% | 2684 fps | 99.5% |
| Bofors RP3 | <<locked>> | 92% | 53,287 psi | 87% | 2707 fps | 100% |
| Bofors RP7 | <<locked>> | 96% | 53,621 psi | 88% | 2674 fps | 97.2% |
| Hodgdon Benchmark | <<locked>> | 84% | 53,171 psi | 87% | 2608 fps | 100% |
| Hodgdon BL-C2 | <<locked>> | 86% | 53,838 psi | 88% | 2703 fps | 100% |
| Hodgdon CFE223 | <<locked>> | 82% | 51,822 psi | 85% | 2740 fps | 99.8% |
| Hodgdon H380 | <<locked>> | 92% | 54,317 psi | 89% | 2717 fps | 99.4% |
| Hodgdon H414 | <<locked>> | 98% | 53,563 psi | 88% | 2762 fps | 98% |
| Hodgdon H4350 | <<locked>> | 96% | 54,520 psi | 90% | 2726 fps | 96.8% |
| Hodgdon H4895 | <<locked>> | 86% | 52,750 psi | 87% | 2680 fps | 100% |
| Hodgdon Hybrid 100Vᴾ | <<locked>> | 100% | 48,457 psi | 80% | 2651 fps | 99.9% |
| Hodgdon LEVERevolution | <<locked>> | 88% | 51,605 psi | 85% | 2710 fps | 100% |
| Hodgdon Superformance | <<locked>> | 98% | 54,360 psi | 89% | 2799 fps | 97.6% |
| Hodgdon TrailBossᴾ | <<locked>> | 100% | 35,331 psi | 58% | 1621 fps | 100% |
| Hodgdon VARGET | <<locked>> | 88% | 53,925 psi | 89% | 2684 fps | 100% |
| IMR 3031 | <<locked>> | 86% | 52,446 psi | 86% | 2664 fps | 100% |
| IMR 4064 | <<locked>> | 90% | 52,678 psi | 86% | 2654 fps | 99.8% |
| IMR 4166 Enduron | <<locked>> | 88% | 52,779 psi | 87% | 2635 fps | 97.6% |
| IMR 4350ᴾ | <<locked>> | 100% | 53,621 psi | 88% | 2697 fps | 97.3% |
| IMR 4451 Enduron | <<locked>> | 94% | 52,330 psi | 86% | 2657 fps | 97.5% |
| IMR 4831ᴾ | <<locked>> | 100% | 51,140 psi | 84% | 2707 fps | 99.5% |
| IMR 4895 | <<locked>> | 90% | 54,723 psi | 90% | 2740 fps | 100% |
| IMR 8208 XBR | <<locked>> | 86% | 54,665 psi | 90% | 2671 fps | 100% |
| Lovex D073.5 | <<locked>> | 82% | 54,737 psi | 90% | 2657 fps | 100% |
| Lovex D073.6 | <<locked>> | 88% | 55,071 psi | 90% | 2694 fps | 100% |
| Lovex S060 | <<locked>> | 86% | 52,141 psi | 86% | 2605 fps | 99.9% |
| Lovex S062 | <<locked>> | 90% | 52,272 psi | 86% | 2648 fps | 100% |
| Lovex S065 | <<locked>> | 98% | 54,810 psi | 90% | 2700 fps | 99% |
| Lovex S070 | <<locked>> | 98% | 52,141 psi | 86% | 2680 fps | 97.8% |
| Norma 201 | <<locked>> | 88% | 54,201 psi | 89% | 2664 fps | 100% |
| Norma 202 | <<locked>> | 88% | 54,694 psi | 90% | 2667 fps | 100% |
| Norma 203B | <<locked>> | 90% | 52,605 psi | 86% | 2697 fps | 99.9% |
| Norma 204ᴾ | <<locked>> | 100% | 54,230 psi | 89% | 2743 fps | 96.1% |
| Norma URPᴾ | <<locked>> | 100% | 53,098 psi | 87% | 2753 fps | 99.6% |
| Ramshot Big Game | <<locked>> | 90% | 53,084 psi | 87% | 2723 fps | 99.9% |
| Ramshot Hunterᴾ | <<locked>> | 100% | 52,083 psi | 86% | 2749 fps | 98.4% |
| Ramshot TAC | <<locked>> | 86% | 54,940 psi | 90% | 2694 fps | 99.1% |
| Ramshot Wild Boar | <<locked>> | 86% | 54,389 psi | 89% | 2710 fps | 100% |
| Ramshot X-Terminator | <<locked>> | 82% | 52,054 psi | 85% | 2625 fps | 99.9% |
| ReloadSwiss RS 14ᴾ | <<locked>> | 100% | 35,708 psi | 59% | 1660 fps | 100% |
| ReloadSwiss RS 40 | <<locked>> | 82% | 54,056 psi | 89% | 2651 fps | 100% |
| ReloadSwiss RS 50 | <<locked>> | 92% | 54,766 psi | 90% | 2700 fps | 98.5% |
| ReloadSwiss RS 52 | <<locked>> | 88% | 53,824 psi | 88% | 2776 fps | 99.9% |
| ReloadSwiss RS 60 | <<locked>> | 94% | 53,113 psi | 87% | 2805 fps | 100% |
| ReloadSwiss RS 62ᴾ | <<locked>> | 100% | 53,722 psi | 88% | 2789 fps | 99.6% |
| ReloadSwiss RS 70ᴾ | <<locked>> | 100% | 53,751 psi | 88% | 2815 fps | 99.4% |
| Rottweil R 901 | <<locked>> | 84% | 52,228 psi | 86% | 2602 fps | 100% |
| Rottweil R 902 | <<locked>> | 90% | 54,723 psi | 90% | 2664 fps | 100% |
| Rottweil R 903 | <<locked>> | 94% | 53,113 psi | 87% | 2697 fps | 100% |
| Rottweil R 907 | <<locked>> | 96% | 53,621 psi | 88% | 2674 fps | 97.2% |
| Shooters World Long Rifle | <<locked>> | 98% | 54,810 psi | 90% | 2700 fps | 99% |
| Shooters World Match Rifle | <<locked>> | 88% | 55,071 psi | 90% | 2694 fps | 100% |
| Shooters World Precision | <<locked>> | 90% | 52,272 psi | 86% | 2648 fps | 100% |
| Shooters World SW4350 | <<locked>> | 98% | 52,141 psi | 86% | 2680 fps | 97.8% |
| SNPE Vectan SP 11 | <<locked>> | 94% | 54,723 psi | 90% | 2753 fps | 100% |
| SNPE Vectan SP 7 | <<locked>> | 86% | 53,142 psi | 87% | 2667 fps | 99.2% |
| SNPE Vectan SP 9 | <<locked>> | 88% | 53,940 psi | 89% | 2694 fps | 100% |
| SNPE Vectan Tubal 3000 | <<locked>> | 86% | 52,605 psi | 86% | 2562 fps | 100% |
| SNPE Vectan Tubal 5000 | <<locked>> | 92% | 52,649 psi | 86% | 2562 fps | 100% |
| SNPE Vectan Tubal 7000 | <<locked>> | 96% | 51,663 psi | 85% | 2602 fps | 97.4% |
| Somchem S321 | <<locked>> | 82% | 52,243 psi | 86% | 2654 fps | 100% |
| Somchem S335 | <<locked>> | 88% | 55,114 psi | 90% | 2602 fps | 100% |
| Somchem S341 | <<locked>> | 86% | 52,692 psi | 87% | 2661 fps | 99.9% |
| Somchem S355 | <<locked>> | 94% | 53,476 psi | 88% | 2694 fps | 100% |
| Somchem S365ᴾ | <<locked>> | 100% | 47,645 psi | 78% | 2707 fps | 100% |
| Vihtavuori N130 | <<locked>> | 82% | 52,475 psi | 86% | 2526 fps | 100% |
| Vihtavuori N133 | <<locked>> | 86% | 52,808 psi | 87% | 2549 fps | 100% |
| Vihtavuori N135 | <<locked>> | 90% | 54,230 psi | 89% | 2625 fps | 100% |
| Vihtavuori N140 | <<locked>> | 88% | 51,866 psi | 85% | 2602 fps | 100% |
| Vihtavuori N150 | <<locked>> | 96% | 55,013 psi | 90% | 2674 fps | 100% |
| Vihtavuori N160 | <<locked>> | 98% | 52,446 psi | 86% | 2700 fps | 99.4% |
| Vihtavuori N530 | <<locked>> | 86% | 55,013 psi | 90% | 2671 fps | 100% |
| Vihtavuori N540 | <<locked>> | 90% | 53,258 psi | 87% | 2644 fps | 100% |
| Vihtavuori N550ᴾ | <<locked>> | 100% | 54,824 psi | 90% | 2756 fps | 99.6% |
| Vihtavuori N555ᴾ | <<locked>> | 100% | 40,234 psi | 66% | 2592 fps | 98.4% |
| Winchester 6.5 StaBALL | <<locked>> | 98% | 52,794 psi | 87% | 2684 fps | 100% |
| Winchester 748 | <<locked>> | 86% | 54,926 psi | 90% | 2720 fps | 100% |
| Winchester 760 | <<locked>> | 98% | 53,751 psi | 88% | 2766 fps | 98% |
| Winchester StaBALL HDᴾ | <<locked>> | 100% | 33,170 psi | 54% | 2513 fps | 98.2% |
| Winchester StaBALL Match | <<locked>> | 88% | 53,606 psi | 88% | 2700 fps | 100% |
Recommended = one of the top powders for this cartridge and bullet combination.
Start Load - Barrel Length: 25.6"
| Powder | Charge | FR | MaxP | % | V(0) | z |
|---|---|---|---|---|---|---|
| Accurate 2015 | <<locked>> | 80% | 47,036 psi | 77% | 2490 fps | 100% |
| Accurate 2460 | <<locked>> | 80% | 51,285 psi | 84% | 2598 fps | 100% |
| Accurate 2495 | <<locked>> | 80% | 39,610 psi | 65% | 2421 fps | 100% |
| Accurate 2520 | <<locked>> | 80% | 46,383 psi | 76% | 2562 fps | 100% |
| Accurate 2700 | <<locked>> | 86% | 47,630 psi | 78% | 2539 fps | 95.7% |
| Accurate 4064 | <<locked>> | 80% | 37,449 psi | 61% | 2415 fps | 100% |
| Accurate 4350 | <<locked>> | 86% | 33,446 psi | 55% | 2398 fps | 95.8% |
| ADI AR 2206H | <<locked>> | 80% | 43,120 psi | 71% | 2520 fps | 99.1% |
| ADI AR 2208 | <<locked>> | 80% | 36,753 psi | 60% | 2382 fps | 97.3% |
| ADI Benchmark 8208 | <<locked>> | 80% | 45,194 psi | 74% | 2526 fps | 99.9% |
| Alliant AR-Comp | <<locked>> | 80% | 45,353 psi | 74% | 2513 fps | 100% |
| Alliant Power Pro 2000-MR | 69.8 gr | 80% | 39,073 psi | 64% | 2549 fps | 97.8% |
| Alliant Reloder- TS 15.5 | <<locked>> | 80% | 36,318 psi | 60% | 2405 fps | 98.6% |
| Alliant Reloder-15 | <<locked>> | 80% | 38,914 psi | 64% | 2461 fps | 98% |
| Alliant Reloder-16 | <<locked>> | 86% | 33,982 psi | 56% | 2411 fps | 95.9% |
| Alliant Reloder-17 | 68.8 gr | 80% | 31,314 psi | 51% | 2372 fps | 96.7% |
| Alliant Reloder-23 | <<locked>> | 92% | 29,167 psi | 48% | 2316 fps | 95.4% |
| Alliant Reloder-26 | <<locked>> | 96% | 35,940 psi | 59% | 2543 fps | 95.8% |
| Baschieri & Pellagri 107 | <<locked>> | 80% | 42,235 psi | 69% | 2526 fps | 98.2% |
| Bofors RP3 | <<locked>> | 80% | 35,868 psi | 59% | 2408 fps | 98.6% |
| Bofors RP7 | <<locked>> | 90% | 44,585 psi | 73% | 2526 fps | 95.2% |
| Hodgdon Benchmark | <<locked>> | 80% | 47,195 psi | 77% | 2520 fps | 100% |
| Hodgdon BL-C2 | <<locked>> | 80% | 43,888 psi | 72% | 2549 fps | 99.9% |
| Hodgdon CFE223 | <<locked>> | 80% | 48,457 psi | 80% | 2687 fps | 99.5% |
| Hodgdon H380 | <<locked>> | 80% | 36,753 psi | 60% | 2408 fps | 96.2% |
| Hodgdon H414 | <<locked>> | 90% | 41,220 psi | 68% | 2552 fps | 95.1% |
| Hodgdon H4350 | <<locked>> | 92% | 48,095 psi | 79% | 2625 fps | 95.4% |
| Hodgdon H4895 | <<locked>> | 80% | 43,526 psi | 71% | 2533 fps | 99.5% |
| Hodgdon Hybrid 100V | <<locked>> | 84% | 29,298 psi | 48% | 2264 fps | 95.9% |
| Hodgdon LEVERevolution | <<locked>> | 80% | 39,508 psi | 65% | 2507 fps | 99.3% |
| Hodgdon Superformance | <<locked>> | 92% | 44,048 psi | 72% | 2621 fps | 95.2% |
| Hodgdon TrailBoss | <<locked>> | 80% | 26,324 psi | 43% | 1447 fps | 100% |
| Hodgdon VARGET | <<locked>> | 80% | 41,814 psi | 69% | 2487 fps | 99.3% |
| IMR 3031 | <<locked>> | 80% | 43,076 psi | 71% | 2526 fps | 100% |
| IMR 4064 | <<locked>> | 80% | 38,580 psi | 63% | 2411 fps | 98% |
| IMR 4166 Enduron | <<locked>> | 82% | 43,714 psi | 72% | 2480 fps | 95.6% |
| IMR 4350 | <<locked>> | 94% | 44,512 psi | 73% | 2549 fps | 95.3% |
| IMR 4451 Enduron | <<locked>> | 88% | 43,526 psi | 71% | 2507 fps | 95.5% |
| IMR 4831 | <<locked>> | 86% | 32,460 psi | 53% | 2359 fps | 95.4% |
| IMR 4895 | <<locked>> | 80% | 39,856 psi | 65% | 2490 fps | 98.7% |
| IMR 8208 XBR | <<locked>> | 80% | 45,194 psi | 74% | 2526 fps | 99.9% |
| Lovex D073.5 | <<locked>> | 80% | 51,097 psi | 84% | 2608 fps | 100% |
| Lovex D073.6 | <<locked>> | 80% | 42,119 psi | 69% | 2503 fps | 100% |
| Lovex S060 | <<locked>> | 80% | 43,497 psi | 71% | 2464 fps | 99.2% |
| Lovex S062 | <<locked>> | 80% | 38,551 psi | 63% | 2418 fps | 99.3% |
| Lovex S065 | <<locked>> | 86% | 37,971 psi | 62% | 2408 fps | 95.5% |
| Lovex S070 | <<locked>> | 90% | 40,669 psi | 67% | 2484 fps | 95.1% |
| Norma 201 | <<locked>> | 80% | 42,366 psi | 70% | 2477 fps | 99.7% |
| Norma 202 | <<locked>> | 80% | 42,627 psi | 70% | 2487 fps | 100% |
| Norma 203B | <<locked>> | 80% | 38,290 psi | 63% | 2451 fps | 98.4% |
| Norma 204 | <<locked>> | 98% | 50,705 psi | 83% | 2687 fps | 95.3% |
| Norma URP | <<locked>> | 86% | 33,924 psi | 56% | 2402 fps | 95.7% |
| Ramshot Big Game | <<locked>> | 80% | 37,739 psi | 62% | 2461 fps | 98.1% |
| Ramshot Hunter | <<locked>> | 92% | 40,219 psi | 66% | 2539 fps | 95.8% |
| Ramshot TAC | <<locked>> | 80% | 45,194 psi | 74% | 2536 fps | 97.6% |
| Ramshot Wild Boar | <<locked>> | 80% | 44,498 psi | 73% | 2552 fps | 99.3% |
| Ramshot X-Terminator | <<locked>> | 80% | 48,892 psi | 80% | 2575 fps | 99.7% |
| ReloadSwiss RS 14 | <<locked>> | 80% | 26,614 psi | 44% | 1483 fps | 100% |
| ReloadSwiss RS 40 | <<locked>> | 80% | 50,691 psi | 83% | 2605 fps | 100% |
| ReloadSwiss RS 50 | <<locked>> | 82% | 39,711 psi | 65% | 2444 fps | 95.2% |
| ReloadSwiss RS 52 | <<locked>> | 80% | 40,756 psi | 67% | 2559 fps | 98.4% |
| ReloadSwiss RS 60 | 68.8 gr | 80% | 33,344 psi | 55% | 2434 fps | 99.4% |
| ReloadSwiss RS 62 | <<locked>> | 86% | 33,199 psi | 55% | 2411 fps | 95.1% |
| ReloadSwiss RS 70 | <<locked>> | 88% | 35,926 psi | 59% | 2470 fps | 95.1% |
| Rottweil R 901 | <<locked>> | 80% | 46,369 psi | 76% | 2516 fps | 100% |
| Rottweil R 902 | <<locked>> | 80% | 40,364 psi | 66% | 2434 fps | 99.5% |
| Rottweil R 903 | <<locked>> | 80% | 33,678 psi | 55% | 2352 fps | 97.8% |
| Rottweil R 907 | <<locked>> | 90% | 44,585 psi | 73% | 2526 fps | 95.2% |
| Shooters World Long Rifle | <<locked>> | 86% | 37,971 psi | 62% | 2408 fps | 95.5% |
| Shooters World Match Rifle | <<locked>> | 80% | 42,119 psi | 69% | 2503 fps | 100% |
| Shooters World Precision | <<locked>> | 80% | 38,551 psi | 63% | 2418 fps | 99.3% |
| Shooters World SW4350 | <<locked>> | 90% | 40,669 psi | 67% | 2484 fps | 95.1% |
| SNPE Vectan SP 11 | <<locked>> | 80% | 34,679 psi | 57% | 2402 fps | 97.3% |
| SNPE Vectan SP 7 | <<locked>> | 80% | 43,308 psi | 71% | 2510 fps | 97.7% |
| SNPE Vectan SP 9 | <<locked>> | 80% | 41,713 psi | 68% | 2493 fps | 98.9% |
| SNPE Vectan Tubal 3000 | <<locked>> | 80% | 43,859 psi | 72% | 2431 fps | 100% |
| SNPE Vectan Tubal 5000 | <<locked>> | 80% | 36,376 psi | 60% | 2310 fps | 100% |
| SNPE Vectan Tubal 7000 | <<locked>> | 90% | 42,525 psi | 70% | 2454 fps | 95.4% |
| Somchem S321 | <<locked>> | 80% | 48,791 psi | 80% | 2605 fps | 100% |
| Somchem S335 | <<locked>> | 80% | 43,337 psi | 71% | 2434 fps | 100% |
| Somchem S341 | <<locked>> | 80% | 42,989 psi | 71% | 2507 fps | 99.1% |
| Somchem S355 | <<locked>> | 80% | 34,621 psi | 57% | 2359 fps | 97.9% |
| Somchem S365 | <<locked>> | 80% | 25,092 psi | 41% | 2198 fps | 95.2% |
| Vihtavuori N130 | <<locked>> | 80% | 49,487 psi | 81% | 2487 fps | 100% |
| Vihtavuori N133 | <<locked>> | 80% | 44,121 psi | 72% | 2425 fps | 100% |
| Vihtavuori N135 | <<locked>> | 80% | 39,726 psi | 65% | 2415 fps | 100% |
| Vihtavuori N140 | <<locked>> | 80% | 40,292 psi | 66% | 2425 fps | 100% |
| Vihtavuori N150 | <<locked>> | 80% | 32,837 psi | 54% | 2300 fps | 98.6% |
| Vihtavuori N160 | <<locked>> | 84% | 33,257 psi | 55% | 2349 fps | 95.3% |
| Vihtavuori N530 | <<locked>> | 80% | 45,382 psi | 75% | 2526 fps | 99.9% |
| Vihtavuori N540 | <<locked>> | 80% | 38,827 psi | 64% | 2415 fps | 100% |
| Vihtavuori N550 | <<locked>> | 86% | 34,853 psi | 57% | 2405 fps | 95.7% |
| Vihtavuori N555 | <<locked>> | 92% | 31,111 psi | 51% | 2388 fps | 95.6% |
| Winchester 6.5 StaBALL | <<locked>> | 80% | 29,211 psi | 48% | 2228 fps | 95.9% |
| Winchester 748 | <<locked>> | 80% | 44,802 psi | 74% | 2569 fps | 100% |
| Winchester 760 | <<locked>> | 90% | 41,220 psi | 68% | 2552 fps | 95.1% |
| Winchester StaBALL HD | <<locked>> | 96% | 29,240 psi | 48% | 2388 fps | 95.9% |
| Winchester StaBALL Match | <<locked>> | 80% | 41,046 psi | 67% | 2497 fps | 99.2% |
Recommended = one of the top powders for this cartridge and bullet combination.
ᴾ possible press load - work up slowly to this load while watching for signs of excessive pressure.
This overview compares 98 powders for .375 Blaser Mag. loaded with the .375 | 270gr | Nosler CT FailSafe. Alliant Power Pro 2000-MR delivers the highest muzzle velocity at 2,835 fps; across all powders the maximum-charge window runs from 1,621 fps to 2,835 fps. Accurate 4350 gives the best case fill at 100 %, and 98 of the 98 powders fall inside the usable 80–100 % fill window.
Relative to the caliber's maximum pressure (420 MPa), the top charges use 54–90 %, leaving at least 10 % headroom. The 270.0 gr projectile in 0.375" calls for a 1:16.5 twist; slower twists will usually not stabilise this weight. Accurate 4350, Alliant Reloder-16, Alliant Reloder-23 reach 100 % fill or more at maximum charge, so these are compressed loads: they need a long drop tube to seat cleanly and react sensitively to the case capacity of your own brass lot. ReloadSwiss RS 60, Alliant Reloder-17, Alliant Power Pro 2000-MR rank at the top here: for .375 Blaser Mag. with the .375 | 270gr | Nosler CT FailSafe they combine a high case fill with complete burn and sit in the upper velocity band. Always begin at the start load and work up in small increments while checking case and primer for pressure signs.